In this project we employ computer simulation techniques to improve the fundamental understanding of how electromagnetic radiation interacts with biological matter.
Funded by the NHMRC Center of Research Excellence “Australian Center for Electromagnetic Bioeffects Research” (ACEBR) 2013-2017. where our team employs computer modelling techniques to study the molecular level response of proteins and biological membranes to electromagnetic radiation in order to develop a fundamental understanding of possible health implications of the widespread use of mobile and wireless communication devices.
The world's population is increasingly exposed to new physical and chemical agents in the environment, some of which may be beneficial and others, damaging to health. Among these new agents, electromagnetic fields (EMF) are becoming more widespread, and their application in new technologies continues to grow, with novel uses being actively developed and commercialised. In particular, the electromagnetic (EM) energy that powers mobile technologies is now affecting over 5 billion phone subscribers world-wide, so the community concern about the possibility of associated health effects is also growing. The mechanisms of non-thermal EMF effects on biological systems, such as proteins and membranes, are not well understood, however, it is believed that EMFs (at certain intensities and frequencies) can cause structural changes which can alter molecular conformation and ultimately the function of biological molecules.
Our team conducts fundamental studies of the molecular structure and dynamics of proteins, peptides and biological membranes exposed to external non-ionising electromagnetic fields typically produced by mobile electronic devices. The latest techniques in computational modelling of biomolecules at all-atom resolution will be employed to explore the molecular mechanisms of their response to the electromagnetic radiation. The studies will help understand potential health implications of mobile technologies and inform safety standards for their manufacturing.
- S. P. Loughran, Md S. Al Hossain, A. Bentvelzen, M. Elwood, J. Finnie, J. Horvat, S. Iskra, E. P. Ivanova, J. Manavis, C. K. Mudiyanselage, A. Lajevardipour, B. Martinac, R. McIntosh, R. McKenzie, M. Mustapic, Y. Nakayama, E. Pirogova, M. H. Rashid, N. A. Taylor, N. Todorova, P. M. Wiedemann, R. Vink, A. Wood, I. Yarovsky, R. J. Croft “Bioelectromagnetics Research within an Australian Context: The Australian Centre for Electromagnetic Bioeffects Research (ACEBR)” International Journal of Environmental Research and Public Health, 3(10), 967 (2016)
- N. Todorova, A. Bentvelzen, N. J. English, I Yarovsky, "Electromagnetic-field effects on structure and dynamics of amyloidogenic peptides" J. Chem. Phys. 144(8): 085101 (2016)
- A. Budi, F.S. Legge, H. Treutlein, I. Yarovsky, "Comparative Study of Insulin Chain-B in Isolated and Monomeric Environments under External Stress" J. Phys. Chem. B, 112(26):7916-7924 (2008)
- A. Budi, F.S. Legge, H. Treutlein, I. Yarovsky, "Effect of Frequency on Insulin Response to Electric Field Stress" J. Phys. Chem. B, 111(20):5748-5756 (2007)
- F.S. Legge, A. Budi, H. Treutlein, I. Yarovsky, "Protein Flexibility: Multiple Molecular Dynamics Simulations of Insulin Chain B" Biophys. Chem., 119(2):146-157 (2006)
- A. Budi, F.S. Legge, H. Treutlein, I. Yarovsky, "Electric Field Effects on Insulin Chain-B Conformation" J. Phys. Chem. B, 109(47):22641-22648 (2005)
- A. Budi, F.S. Legge, H. Treutlein, I. Yarovsky, "Protein Response to Electric Field Stress" Proceedings of the 16th Australian Institute of Physics Congress 2005 Canberra, Australia (2005) ISBN 0-9598064-8-2
- A. Budi, F.S. Legge, H. Treutlein, I. Yarovsky, "Effect of External Stresses on Protein Conformation: A Computer Modelling Study" Eur. Biophys. J., 33(2):121-129 (2004)