Ion channels are responsible for electrical signaling in brain and muscle. We are interested in understanding the detailed molecular mechanisms underlying ion channel function, dysfunction in disease and regulation by both physiological modulators and drugs. We use a combination of molecular modeling, experimental structure-function studies and animal models. Main projects include:
GABAA receptor pharmacology and pathology. The GABAA receptor regulates brain electrical activity and is a major target for drugs such as anti-anxiety treatments, anaesthetics, alcohol and barbiturates, whilst mutations in GABAA genes can lead to epilepsy. By understanding the molecular details involved, we aim to help the development of better drugs.
Modulation of ClC-1 by ATP; a role in fatigue?
ClC-1 regulates skeletal muscle activation, with mutations in the gene leading to loss of muscle control in the disease, myotonia congenita. We have shown that ATP and acidosis regulate ClC-1 function, which may be a factor in muscle fatigue during intense exercise.
Group Leader: Ion Channel Molecular Mechanisms Group
- B.Sc (Hons), Australian National University, 1990
- PhD (Medical Sciences), Australian National University, 1998
- Australian Physiological Society (AuPS)
- Australian Society for Biophysics (ASB)
- Australian Society for Biochemistry and Molecular Biology (ASBMB)
- Biophysical Society, USA
- Understanding how chloride channels function and their role in muscle fatigue and disease (NHMRC, 2009-2011 $466,250)
- Targeting Spinal Cord Ion Channels to Treat Chronic Pain (ANZ Trustees, 2011, $20,000)
- 2007 Heymanson Fellowship (3yrs), Melbourne University
- 2006 St. Vincent’s Research Week, Senior Biochemistry Poster prize
- 2005 St. Vincent’s Research Week, Senior Biochemistry Poster prize.
- 1997 Australian Society for Biochemistry and Molecular Biology - travel fellowship
- 1996 COMBIO conference, Student poster prize, Canberra.
- Lynagh, T.,Beech, R.,Lalande, M.,Keller, K.,Cromer, B.,Wolstenholme, A.,Laube, B. (2015). Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels In: Scientific Reports, 5, 1 - 8
- Wong, L.,Tae, H.,Cromer, B. (2015). Assembly, trafficking and function of a1ß2y2 GABA(A) receptors are regulated by N-terminal regions, in a subunit-specific manner In: Journal of Neurochemistry, 134, 819 - 832
- Lynagh, T.,Cromer, B.,Dufour, V.,Laube, B. (2014). Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics In: International Journal for Parasitology: Drugs and Drug Resistance, 4, 244 - 255
- Wong, L.,Tae, H.,Cromer, B. (2014). Role of the rho 1 GABA(C) receptor n-terminus in assembly, trafficking and function In: ACS Chemical Neuroscience, 5, 1266 - 1277
- Unkles, S.,Karabika, E.,Symington, V.,Cecile, J.,Rouch, D.,Akhtar, N.,Cromer, B.,Kinghorn, J. (2012). Alanine scanning mutagenesis of a high-affinity nitrate transporter highlights the requirement for glycine and asparagine residues in the two nitrate signature motifs In: Biochemical Journal, 447, 35 - 42
- Ascher, D.,Cromer, B.,Morton, C.,Volitakis, I.,Cherny, R.,Albiston, A.,CHAI, S.,Parker, M. (2011). Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain In: Biochemistry, 50, 2611 - 2622
- Gazina, E.,Smidansky, E.,Holien, J.,Harrison, D.,Cromer, B.,Arnold, J.,Parker, M.,Cameron, C.,Petrou, S. (2011). Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase In: Journal of Virology, 85, 10364 - 10374
- Lynagh, T.,Webb, T.,Dixon, C.,Cromer, B.,Lynch, J. (2011). Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel In: The Journal of Biological Chemistry, 286, 43913 - 43924
- Stokes, L.,Scurrah, K.,Ellis, J.,Cromer, B.,Skarratt, K.,Gu, B.,Harrap, S.,Wiley, J. (2011). A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure In: Hypertension, 58, 1086 - 1092
- Yin, W.,Majumder, S.,Clayton, T.,Petrou, S.,VanLinn, M.,Namjoshi, O.,Ma, C.,Cromer, B.,Roth, B.,Platt, D.,Cook, J. (2010). Design, synthesis, and subtype selectivity of 3,6-disubstituted b-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse In: Bioorganic & Medicinal Chemistry, 18, 7548 - 7564
- How do anaesthetics work? A rational basis for safer general anaesthesia.. Funded by: National Health and Medical Research Council (NHMRC) Project Grants 2016 from (2016 to 2018)
- International Speakers for the 2015 Gage Conference on Ion Channels and Transporters. Funded by: Ian Potter Foundation Travel Grant 2014 Round 2 from (2015 to 2015)
- Targeting Spinal Cord Ion Channels to Treat Chronic Pain. Funded by: ANZ Charitable Trust. Medical Research & Technology in Victoria Grant Application from (2011 to 2011)
- CBS domain modulation of muscle chloride channels; molecular mechanism and physiological role.. Funded by: National Health and Medical Research Council (NHMRC) Project Grant Pre-2014 from (2009 to 2012)
1 PhD Current Supervisions2 PhD Completions