STAFF PROFILE
Professor Peter Little AM
Position:
Adjunct Professor
College / Portfolio:
STEM College
Phone:
+61399257115
Email:
peter.little@rmit.edu.au
Campus:
City Campus
- Receptor transactivation in vascular disease. Funded by: National Health and Medical Research Council (NHMRC) Project Grant Pre-2014 from (2012 to 2015)
- NHMRC Standard Equipment Grant 2012. Funded by: NHMRC Equipment Only Grants from (2012 to 2012)
- Linker region phosphorylated Smad2 as a novel target for the prevention of atherosclerosis. Funded by: National Heart Foundation of Australia Grants-in-Aid Grant Pre-2014 from (2011 to 2012)
- A novel link between G protein coupled and serine/theonine receptors regulating Proteoglycan synthesis in smooth muscle. Funded by: GlaxoSmithKline Post Graduate Support Grant from (2011 to 2011)
- PDGF receptor tyrosine activity in the regulation of proteoglcyan synthesis invascular smooth muscle. Funded by: National Heart Foundation of Australia Grants-in-Aid Grant Pre-2014 from (2010 to 2011)
5 PhD Completions
Diabetes, Cardiovascular complications of diabetes, Vascular biology and pathology, Pharmacy, Pharmacy practice.
- Kamato, D.,Gabr, M.,Kumarapperuma, H.,Chia, Z.,Zheng, W.,Xu, S.,Osman, N.,Little AM, P. (2022). Gaq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells In: International Journal of Molecular Sciences, 23, 1 - 13
- Rostam, M.,Shajimoon, A.,Kamato, D.,Mitra, P.,Piva, T.,Getachew, R.,Cao, Y.,Zheng, W.,Osman, N.,Little AM, P. (2018). Flavopiridol inhibits TGF-ß-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2536 In: Journal of Pharmacology and Experimental Therapeutics, 365, 156 - 164
- Afroz, R.,Cao, Y.,Rostam, M.,Ta, H.,Xu, S.,Zheng, W.,Osman, N.,Kamato, D.,Little AM, P. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis In: Pharmacology & Therapeutics, 187, 88 - 97
- Kamato, D.,Bhaskarla, V.,Mantri, N.,Oh, T.,Ling, D.,Janke, R.,Zheng, W.,Little AM, P.,Osman, N. (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells In: PLoS One, 12, 1 - 28
- Little AM, P.,Hollenberg, M.,Kamato, D.,Thomas, W.,Zheng, W.,Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling In: British Journal of Pharmacology, 173, 2992 - 3000
- Rostam, M.,Kamato, D.,Piva, T.,Zheng, W.,Little AM, P.,Osman, N. (2016). The role of specific Smad linker region phosphorylation in TGF-beta mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle In: Cellular Signalling, 28, 956 - 966
- Chan, V.,Mishriky, J.,Balassone, J.,Bashour, Z.,Kaur, S.,Raman, V.,Getachew, R.,Osman, N.,Guidone, D.,Little AM, P. (2016). An investigation of Sodium Fusidate and recombinant Cytochrome P450 enzymes inhibition in-vitro In: Drug metabolism letters, 10, 1 - 7
- Algwairi, O.,Osman, N.,Getachew, R.,Zheng, W.,Liang, X.,Kamato, D.,Thach, L.,Little AM, P. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells In: International Journal of Biological Sciences, 12, 1041 - 1051
- Algwairi, O.,Thach, L.,Zheng, W.,Osman, N.,Little AM, P. (2016). Cellular and molecular pathology of age-related macular degeneration: Potential role for proteoglycans In: Journal of Ophthalmology, 2016, 1 - 7
- Kamato, D.,Mitra, P.,Davis, F.,Osman, N.,Chaplin, R.,Cabot, P.,Afroz, R.,Thomas, W.,Zheng, W.,Kaur, H.,Brimble, M.,Little AM, P. (2016). Gaq proteins: molecular pharmacology and therapeutic potential In: Cellular and Molecular Life Sciences, 74, 1379 - 1390