Dr Martin Stebbing's major area of research interest is the neurobiology of neuropathic pain and the physiology of sensory systems in the periphery and the spinal cord. Neuropathic pain can follow many kinds of damage to the nervous system, including diabetic neuropathy, infection, trauma (eg car accidents) or iatrogenic injury during surgery (eg. mastectomy, thoracotomy and gall bladder removal). Currently available treatments are inadequate and the mechanisms causing neuropathic pain are still not properly understood. Changes in damaged sensory neurons with cell bodies in the dorsal root ganglia may contribute to the pathology. Changes within the dorsal horn of the spinal cord have also been implicated. The dorsal horn is the first point of processing of somatic and visceral sensory information within the central nervous system.
The aim of his research is to develop a better understanding of the function of the dorsal horn and the changes in the nervous system that lead to neuropathic pain. He has taken a multidisciplinary approach to investigating how sensory neural circuits are wired up and how they function. He has utilised several different methods including electrophysiological recordings from single cells using patch clamp, combined with 3-dimensional reconstructions of neuronal morphology using confocal microscopy.
Dr Stebbing is affiliated with the Neuropharmacology and neuroinflammatory research area at RMIT and the Autonomic Neuroscience/Pain and Sensory Mechanisms Laboratory at the University of Melbourne
He has successfully supervised doctoral candidates and currently supervise several students, at both PhD and honours level.
- 1997-1999 UNSW Vice Chancellor’s Postdoctoral Fellowship
- 1998 Tow Research Awards - Poster Prize.
- 2000 Canadian Neurotrauma Fellowship, Canadian Institutes of Health Research
Use of protein kinase C inhibitor for suppressing sustained slow postsynaptic excitation (SSPE).In the name of Pfizer International: Inventors, JB Furness and MJ Stebbing, US Patent 60/458673 (2003)
At present my teaching responsibilities include teaching in the Physiology, Neuroscience and Cell Biology disciplines. This includes teaching into the Biotechnology and Biomedical Sciences - Bachelor of Applied Science, Chinese Medicine, Chiropractic, Osteopathy and Human Movement programs.
- PhD (Medicine), University of Melbourne, 1996
- B.Sc. (Hons), University of Melbourne, 1991
Dr Stebbing is currently a member of the following societies:
- The Australian Neuroscience Society (ANS)
- 2004 Symposium organiser, National Scientific Conference; Principal organiser Satellite symposium entitled “Understanding Pain - Biology to Behaviour”
- The Australian Physiological Society (AuPS)
- The Australian Society for Medical Research (ASMR)
- 1999 NSW Membership Convenor, co-chair NSW state conference organising committee, author state and national conference websites.
- The International Society for Autonomic Neuroscience (ISAN)
- 1997 Organiser international congress events and jobs forum, author young scientists web page.
- The Society for Neuroscience (USA)
- He is a regular reviewer of articles submitted to journals such as the Journal of Physiology, British Journal of Pharmacology, Neuroscience Letters and Digestive Diseases and Sciences, and of grant applications to the National Health and Medical Research Council and the Australian Research Council.
- In October 2003 he took part in the Science Meets Parliament day organised by the Federation of Australian Science and Technology Societies. He has met with politicians to discuss support for scientific research in Australia and gave a radio interview on Plenty Valley FM.
- He is currently Chair of the Neurosciences Victoria Pain Research Program Committee and was manager of the Neurosciences Victoria Cellular Neurophysiology Platform from 2002-2004.
- Stebbing, M.,Balasubramanyan, S.,Smith, P. (2016). Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury In: Neuroscience, 324, 330 - 343
- Habeeballah, H.,Alsuhaymi, N.,Stebbing, M.,Jenkins, T.,Badoer, E. (2016). Central leptin and resistin combined elicits enhanced central effects on renal sympathetic nerve activity In: Experimental Physiology, 101, 791 - 800
- Badoer, E.,Kosari, S.,Stebbing, M. (2015). Resistin, an adipokine with non-generalized actions on sympathetic nerve activity In: Frontiers in Physiology, 6, 1 - 9
- Stebbing, M.,Cottee, J.,Rana, I. (2015). The role of ion channels in microglial activation and proliferation - a complex interplay between ligand-gated ion channels, K+ channels, and intracellular Ca2+ In: Frontiers in Immunology, 6, 1 - 7
- Rana, I.,Badoer, E.,Alahmadi, E.,Leo, C.,Woodman, O.,Stebbing, M. (2014). Microglia are selectively activated in endocrine and cardiovascular control centres in streptozotocin-induced diabetic rats In: Journal of Neuroendocrinology, 26, 413 - 425
- Dworak, M.,Stebbing, M.,Kompa, A.,Rana, I.,Krum, H.,Badoer, E. (2014). Attenuation of microglial and neuronal activation in the brain by ICV minocycline following myocardial infarction In: Autonomic Neuroscience, 185, 43 - 50
- Smolny, M.,Rogers, M.,Shafton, A.,Rush, R.,Stebbing, M. (2014). Development of non-viral vehicles for targeted gene transfer into microglia via the integrin receptor CD11b In: Frontiers in Molecular Neuroscience, 7, 1 - 19
- Kosari, S.,Camera, D.,Hawley, J.,Stebbing, M.,Badoer, E. (2013). ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue In: International Journal of Physiology, Pathophysiology and Pharmacology, 5, 184 - 189
- Dworak, M.,Stebbing, M.,Kompa, A.,Rana, I.,Krum, H.,Badoer, E. (2012). Sustained activation of microglia in the hypothalamic PVN following myocardial infarction In: Autonomic Neuroscience: Basic and Clinical, 169, 70 - 76
- Biggs, J.,Lu, V.,Stebbing, M.,Balasubramanyan, S.,Smith, P. (2010). Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? In: Molecular Pain, 6, 1 - 14
- Role of microglia in diabetic complications and autonomic neuropathy. Funded by: JDRF Innovative Grant pre-2014 from (2010 to 2011)
- Effects of obesity on the brain. Funded by: Diabetes Australia Research Trust Grant Pre-2014 from (2009 to 2009)
- A Fast-Scanning Spectral Confocal Microscope for RMIT Bundoora for use in cardiovascular, diabetes, cancer and neuroscience research. Funded by: Ramaciotti Foundation Equipment Grant pre-2014 from (2009 to 2009)
- An ultrafast scanning confocal microscope for diabetes, obesity, cardiovascular and neuroscience research . Funded by: Perpetual Trustees Australia Grant pre-2014 from (2008 to 2008)
- Mechanisms of Long-term Excitability changes in Enteric neurons. Funded by: National Health and Medical Research Council (NHMRC) Project Grants 2003 from (2004 to 2005)
4 PhD Current Supervisions6 PhD Completions and 1 Masters by Research Completions