Event details Event cancelled
Seminar by Dr Silke HÃ¤rteis, University of Erlangen-Nuremberg, Germany.
The research focus of Dr Silke Härteis (University of Erlangen-Nuremberg, Germany) is the physiology and pathophysiology of epithelial ion channels. She is interested in the molecular mechanisms that regulate these proteins and has extensive experience in their functional study.
Proteolytic activation of protease-activated receptor 2 (PAR2) may represent a major mechanism regulating the transient receptor potential vanilloid 4 (TRPV4), non-selective cation channel in pathophysiological conditions that involve inflammation and protease activation.
In this seminar, Dr Härteis will present findings showing that PAR2-mediated sensitisation of TRPV4 by the serine protease trypsin is independent of intracellular calcium signaling. The “coupling” of TRPV4/PAR2 may be relevant in inflammatory diseases such as arthritis or inflammatory bowel disease, where multiple PAR2-activating proteases are produced. TRPV4 is expressed in a wide range of tissues including prostate and kidney.
Dr Härteis will also present data showing that sensitisation of TRPV4 involving PAR2 may be important for prostate physiology and pathophysiology.