Professor David Pow is Head of the School of Medical Sciences and an active researcher in the area of neurosciences.
The brain uses a number of molecules as excitatory or inhibitory neurotransmitters; the majority of these molecules are amino acids such as glutamate or glycine. Some of these molecules, such as glutamate are implicated in the pathogenesis of diseases such as epilepsy, schizophrenia and Alzheimer's disease.
Professor Pow’s research focuses on analysing the distributions and functions of specialised transporters which are responsible for redistributing amino acid neurotransmitters between sites of synthesis and sites of usage. Cloning new forms of these transporters and creating tools such as antibodies that are directed against these transporters can help detect where they are and determine the role of each transporter in normal and pathological situations in the neonatal and ageing brain.
One aspect of David’s work also involves the development of an understanding of what we call the “transportome“, which is an integrated complex of proteins that determines the overall homeostasis of molecules such as the amino acid neurotransmitters GABA and glutamate in the brain, and thus regulates overall brain excitability. This is important in disease states ranging from schizophrenia through to epilepsy and Alzheimer’s disease.
David’s research is conducted in a very collaborative manner, with new NHMRC funded research being coordinated through RMIT and conducted at RMIT as well as in Queensland and Sydney.
- BSc, Biochemistry, University of Newcastle upon Tyne, UK, 1983
- PhD, University of Newcastle upon Tyne, UK, 1987
Professor Pow has made strong contributions to the national neuroscience community over the past 20 years. He serves on bodies such as the editorial board of Neurochemistry International (Number 2 internationally-ranked neurochemistry journal) as well as normal service duties such as NHMRC GRPs and the Retina Australia Grants Panel. Internationally, he currently serves on a New Zealand HRC panel.
- Kashem, M.,Lee, A.,Pow, D.,Sery, O.,Balcar, V. (2017). Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring? In: Medical Hypotheses, 98, 57 - 59
- Camera, D.,Coleman, H.,Parkington, H.,Jenkins, T.,Pow, D.,Boase, N.,Kumar, S.,Poronnik, P. (2016). Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice In: Behavioural Brain research, 303, 176 - 181
- Lee, A.,Stevens, M.,Anderson, A.,Kwan, A.,Balcar, V.,Pow, D. (2016). A novel splice variant of the Excitatory Amino Acid Transporter 5: Cloning, immunolocalization and functional characterization of hEAAT5v in human retina In: Neurochemistry International, 101, 76 - 82
- Sery, O.,Sultana, N.,Kashem, M.,Pow, D.,Balcar, V. (2015). GLAST but not least-distribution, function, genetics and epigenetics of l-glutamate transport in brain-focus on GLAST/EAAT1 In: Neurochemical Research, 40, 2461 - 2472
- Camera, D.,Boase, N.,Kumar, S.,Pow, D.,Poronnik, P. (2014). Subtle gait abnormalities in Nedd4 heterozygous mice In: Behavioural Brain Research, 260, 15 - 24
- Lee, A.,Anderson, A.,Stevens, M.,Beasley, S.,Barnett, N.,Pow, D. (2013). Excitatory amino acid transporter 5 is widely expressed in peripheral tissues In: European Journal of Histochemistry, 57, 66 - 71
- Lee, .,Anderson, A.,Rayfield, A.,Stevens, M.,Poronnik, P.,Meabon, J.,Cook, D.,Pow, D. (2012). Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis In: Journal of Chemical Neuroanatomy, 43, 64 - 75
- Sullivan, S.,Sullivan, R.,Miller, S.,Ireland, Z.,Bjorkman, S.,Pow, D.,Colditz, P. (2012). Phosphorylation of GFAP is associated with injury in the neonatal pig hypoxic-Ischemic brain In: Neurochemical Research, 37, 2364 - 2378
- Lee, .,Anderson, A.,Barnett, N.,Stevens, M.,Pow, D. (2012). Alternate splicing and expression of the glutamate transporter EAAT5 in the rat retina In: Gene, 506, 283 - 288
- Lee, .,Anderson, A.,Barnett, A.,Chan, A.,Pow, D. (2011). Expression of multiple glutamate transporter splice variants in the rodent testis In: Asian Journal of Andrology, 13, 254 - 265
- NHMRC Equipment Grant 2014. Funded by: NHMRC Equipment Grant from (2014 to 2014)
- A novel mechanism that links brain excitation and inhibition . Funded by: National Health and Medical Research Council (NHMRC) Project Grant Pre-2014 from (2013 to 2016)
- NHMRC Equipment Grant 2013. Funded by: NHMRC Equipment Grant from (2013 to 2013)
- NHMRC Standard Equipment Grant 2012. Funded by: NHMRC Equipment Only Grants from (2012 to 2012)
1 PhD Completions