Biodegradable electrospun nanofibres for medical application (drug delivery system)
Levofloxacin as a model drug was conjugated to the thiol functionalised mesoporous silica naoparticles. EDC was used as crosslinking agent to conjugate the model drug to the functionalised MSNs and form a thioester bond in final product. Conjugation was confirmed by DSC study and Hydrolysis reaction test. Drugconjugated MSNs showed long lasting release profile than drug-loaded MSNs due to the hydrolysis of thioester bonds in conjugated MSNs in a long term. Hydrolysis reaction test showed no release (thioester bonds braking) when it was tested in dichloromethane(CH?Cl?) due to lack of oxygen in the medium to hydrolyse and break the thioester bonds while there is cumulative release of a drug from conjugated MSNs when soaked in buffer saline solution (PBS). Composite drug conjugated MSNs/PCL nanofibers are to be electrospun.