Presented by EU Visiting Fellow César Sanchez Huertas, PhD in Biotechnology, and researcher at the Catalan Institute of Nano-science and Nano-technology (ICN2).
The group Cesar works with have employed two optical biosensors, the well-known SPR biosensor and the multiplexing BiMW interferometer, both of them fully developed in our Group. These platforms permit the analysis of such routes by offering simple, label-free and highly sensitive detection in a few minutes and with minimal sample treatment. Our methodologies resolve the main problems encountered in the standard analysis of these epigenetic processes, demonstrating an excellent selectivity and suitable sensitivities for their physiological contexts.
They have developed an innovative methodology for the direct capture of double-stranded DNA fragments. This facilitates the analysis of the methylation status from concrete gene fragments without the need for DNA strand separation. Our biosensors constitute a breakthrough in epigenetics, representing a highly valuable and innovative tool for cancer prognosis, diagnosis and patient follow-ups.