STAFF PROFILE
Professor Denise Jackson
Position:
Professor
College / Portfolio:
STEM College
School / Department:
STEM|Health and Biomedical Sciences
Phone:
+61399257392
Email:
denise.jackson@rmit.edu.au
Campus:
Bundoora West
Contact me about:
Research supervision,
Media comments
Professor Denise Jackson is the Head of the Thrombosis and Vascular Biology laboratory and is also an Honorary NHMRC fellow.
Research interests
Research in the Thrombosis and Vascular Diseases Research team aims to understand the cellular mechanisms of how blood clots are formed and what leads to stabilisation of blood clots. The research of Associate Professor Jackson and her team ranges from work on the cellular, molecular, physiological and biochemical aspects of thrombosis, to small animal models of in vivo thrombus formation and ischaemic stroke. In addition, research of this team examines the importance of cell surface receptors known as immunoreceptors in infection and immunity, with a particular emphasis on bacterial pathogens.
Research objectives
- To study mechanisms that regulate platelet thrombus formation in mouse models.
- To study immunoreceptors in the immune system in our established models.
- Develop a new understanding on how immunoreceptors recognise and process bacterial pathogens to regulate immunity.
- To gain knowledge on the importance of tetraspanins and immunoreceptors in regulating blood clots.
- To study mechanisms of signaling and compartmentalisation in platelet responsiveness.
- To obtain crystal structures of immunoreceptors and use this information to design drugs.
Educational development work
- Course coordinator of MEDS1142 Medical informatics, BUSM3220 Medical laboratory quality systems and accreditation and ONPS2153 Medical informatics and laboratory management.
- Principal supervisor of research students: 12 Honours, 3 Masters and 4 PhD.
- Self assessment in Haematology programmes (AIMS).
Prof. Jackson's responsibilities include:
- Member of Program Advisory Committee for Laboratory Medicine
- Foster innovation in teaching and learning and improve teaching quality.
- Implement "Program Experience Portfolio".
- Maintain IBMS and AIMS accreditation of Lab Medicine courses.
- Investigate and develop new postgraduate degrees.
- Restructure programs to give students more flexibility.
- Maintain liaison, collaboration and engagement with industry.
- Investigate off-shore opportunities and develop business cases.
Teaching responsibilities
- Course coordinator of MEDS1142 Medical informatics, BUSM3220 Medical laboratory quality systems and accreditation and ONPS2153 Medical informatics and laboratory management.
- Principal supervisor of research students: Honours, Masters and PhD.
- B. App. Sc. (MLS), RMIT, 1982
- FAIMS, Fellow of the Australian Institute of Medical Scientists, 1989
- PhD, Monash University, 1994
Member of professional associations
- Australian Institute of Medical Scientists
- Haematology Society of Australia
- American Society of Hematology
- American Society of Cell Biology
- Australian Vascular Biology Society
- Australian Society for Biochemistry and Molecular Biology
- National Association of Research Fellows
- Australian Society of Immunology
- Member of the International Advisory Board for the XXth Congress of ISTH
- Brain Foundation
- ISTH
Professional and community involvement
- Reviewed project grant applications for the following funding bodies and organisations:
- National Health and Medical Research Council
- National Heart Foundation
- Women's and Children's Hospital, Adelaide. S.A.
- Fellowship Reviews, Monash University, Vic.
- Wellcome Trust, UK.
- National Science Foundation, USA.
- NATA reviewer of Haematology / Immunohaematology laboratories
- Scientific Reviewer for the following journals:
- Australian Institute of Medical Science Journal
- Nature
- Blood
- Thrombosis and Haemostasis
- Journal of Immunology
- Journal of Histochemistry and Cytochemistry
- Journal of Leukocyte Biology
- Journal of Clinical Investigation
- Cell Death and Differentiation
- American Journal of Respiratory Cell and Molecular Biology
- Carmine, H.,Jackson, D. (2023). Relative risk of haemolytic diseases of the foetus and newborn based on maternal alloantibody specificity: systematic review and meta-analysis In: Journal of Blood Disorders and Transfusion, 14, 1 - 8
- Martine, H.,Jackson, D. (2023). Application of the Doppler Ultrasound in detecting foetal anaemia caused by anti-Kell maternal alloimmunisation: systematic review and meta-analysis In: Journal of Blood Disorders and Transfusion, 14, 1 - 8
- Guglielmino, J.,Jackson, D. (2022). Next Generation Sequencing of human platelet antigens for routine clinical investigations and donor screening: systematic review and meta analysis In: Transfusion Medicine Reviews, 36, 87 - 96
- Hamali, H.,Saboor, M.,Dobie, G.,Madkhali, A.,Akhter, M.,Hakamy, A.,Al-Mekhlaf, H.,Jackson, D.,Matari, Y.,Mobarki, A. (2022). Procoagulant microvesicles in COVID-19 patients: possible modulators of inflammation and prothrombotic tendency In: Infection and Drug Resistance, 15, 1 - 10
- Lai, W.,Jackson, D. (2022). Risk of Haematologic Side Effects in Multiple Myeloma Patients Treated with Daratumumab In: Journal of Blood Disorders and Transfusion, 13, 1 - 10
- Guglielmino, J.,Jackson, D. (2022). Emerging trends of next generation sequencing of human platelet antigens in Transfusion Medicine In: Journal of Blood Disorders and Transfusion, 13, 1 - 6
- Kennedy, C.,Jackson, D. (2022). The effect of HLA matching and donor relatedness on the risk of autoimmune haemolytic anaemia in HSCT recipients: A systematic review and meta-analysis In: eJHaem, 3, 609 - 618
- Wong, K.,Lai, R.,Jackson, D. (2022). HLA Class II regulation of immune response in sickle cell disease patients: Susceptibility to red blood cell alloimmunization (systematic review and meta-analysis) In: Vox Sanguinis, 117, 1251 - 1261
- Alwadai, M.,Jackson, D. (2022). The Association of Human Leukocyte DQB1*02:01 Allele with Foetus and Neonatal Alloimmune Thrombocytopenia In: Journal of Blood Disorders & Transfusion, 13, 1 - 8
- Alanazi, F.,Goncalves, I.,Burbury, K.,Kwa, F.,Dobie, G.,Kuriri, F.,Abdalhabib, E.,Jackson, D. (2022). Carfilzomib potentiates platelet activation and thrombus growth In: Journal of Blood Disorders & Transfusion, 13, 1 - 7
- An Investigation of the Adverse Vascular and Thrombotic Effects of the Tyrosine Kinase Inhibitors, Nilotinib and Ponatinib. Funded by: Perpetual Trustees Australia Grant 2014 from (2014 to 2016)
- P2Y12 purinergic receptor and tetraspanins, CD151 and TSSC6 provide an essential link for stable thrombus formation. Funded by: Marion and EH Flack Trust Grant pre-2014 from (2012 to 2012)
- Understanding platelet immunoreceptors in contact-dependent events that modulate platelet thrombus formation. Funded by: Sir Edward Dunlop Medical Research Foundation Project Research Grant pre-2014 from (2011 to 2011)
- Tetraspanins serve as molecular facilitators to regulate platelet thrombus formation.. Funded by: National Health and Medical Research Council (NHMRC) Project Grant Pre-2014 from (2010 to 2012)
- Understanding platelet immunoreceptors in contact-dependent events that modulate platelet thrombus formation. Funded by: National Heart Foundation of Australia Grants-in-Aid Grant Pre-2014 from (2010 to 2011)
Note: Supervision projects since 2004
2 PhD Current Supervisions8 PhD Completions
Thrombosis, platelet biology, mouse models, human platelets, anti-platelet therapy, biochemistry, atherosclerosis, vascular biology.