- Development of therapeutic proteins
- Identifying candidates for poultry vaccines
- Development of vaccines for parasites
- Expression of recombinant proteins in various systems
- Structure and function of proteins
- Recombinant vaccines using commercial Salmonella and Influenza vaccines
In the past five years Professor Smooker has been awarded grants well in excess of $1M to research a variety of projects, focusing on vaccines and the development of therapeutic proteins. These funds have come from the Poultry CRC, ACIAR, the ARC and from industry. These projects have attracted and trained post-doctoral fellows and a number of PhD projects (twelve completions since 2004). Honours students and Master of Biotechnology students undertaking research projects are also trained in the laboratory. Professor Smooker also hosts research scientists on sabbatical leave into the laboratory. The Biotechnology laboratory is a vibrant, multicultural laboratory. If you would like to join, please send him an e-mail. We are looking for excellent students (with the potential to obtain scholarships!).
- Nocturne. Research partnership. Developing recombinant toxin molecules as therapeutic proteins, Commenced 2009.
- BioDiem. Research partnership. Recombinant influenza as a vaccine delivery system. Commenced 2011.
- Tall Bennet. Research partnership. Profiling of yeast additives used in the dairy industry. Commenced 2010.
- Bioproperties. Research partnership/ co-supervision of students. Developing a vaccine against campylobacter. Commenced 2009.
- Orica. Research partnership/ co-supervision of students. Identification of bacteria that degrade explosive residues. Commenced 2009.
- Prince Henry's Institute for Medical Research. Co-supervision of postgraduate students
- Burnett Institute. Co-supervision of postgraduate students
- Institute for Biotechnology, Hanoi, Vietnam. Research partnership.
- Miyagi University, Sendai, Japan. Research partnership, staff and student exchange. Conference chair.
- Monash University. Research partnership.
- Thammasat University, Bangkok, Thailand. Research partnership, student exchange.
- Mahidol University, Bangkok, Thailand. Research partnership, student exchange.
- Ramamalga University, Bangkok, Thailand. Staff training.
- Danish Technical University, Copenhagen, Denmark. Student exchange, research partnership.
- Member of the Scientific Advisory board for a large, multi-country Campylobacter vaccine project, CamVac. This project is headquartered at DTU.
Summary of responsibilities
- Biotechnology Laboratory Head
- Program Leader, Master of Biotechnology
- Core member and research group leader (with Dr Anna Walduck) Health Innovations Research Institute
- School of Applied Sciences Research Strength Leader (Infection and Disease)
- Co-convener, Bundoora Protein group
- International Postgraduate Recruitment
Specialty expertise areas
- Antigen discovery
- Vaccine delivery systems
- Molecular parasitology
- Molecular microbiology
- Protein expression, structure and function
Professor Smooker teaches into a variety of postgraduate and undergraduate programs, and am coordinator of Immunology and Bioinformatics courses. He has also undertaken the provision of short courses both internationally, and hosting international scientists in Australia. Please contact him if your institution is interested in training courses in molecular biology, molecular microbiology, food science, or bioinformatics.
The Master of Biotechnology program that Professor Smooker leads has a large intake of both local and international students; please feel free to contact him for information on the program.
- Bachelor of Science (Honours), Monash University, 1983
- PhD, Monash University, 1988
- Van, T.,Yidana, Z.,Smooker, P.,Coloe, P. (2020). Antibiotic Use in Food Animals in the World with Focus on Africa: Pluses and Minuses In: Journal of Global Antimicrobial Resistance, 20, 170 - 177
- Khalaj-Hedayati, A.,Chua, C.,Smooker, P.,Lee, K. (2020). Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement In: Influenza and other Respiratory Viruses, 14, 92 - 101
- Raeburn, C.,Kasahara, S.,Komoda, T.,Abbott, C.,Smooker, P. (2020). Draft genome sequence and nomenclature adjustment of Rhodococcus qingshengii CS98, a cesium-accumulating strain isolated in Japan In: Biotechnology Reports, 25, 1 - 2
- Penumarthi, A.,Basak, P.,Smooker, P.,Shukla, R. (2020). Hitching a Ride: Enhancing Nucleic Acid Delivery into Target Cells Through Nanoparticles In: Nanoscience in Medicine, Springer Nature, Switzerland
- Taki, A.,Francis, J.,Skakic, I.,Dekiwadia, C.,Mclean, T.,Bansal, V.,Smooker, P. (2020). Protein-only nanocapsules induce cross-presentation in dendritic cells, demonstrating potential as an antigen delivery system In: Nanomedicine: Nanotechnology, Biology and Medicine, 28, 1 - 13
- McLean, T.,Norbury, L.,Conduit, R.,Shepherd, N.,Coloe, P.,Sasse, A.,Smooker, P. (2020). Inactivated tetanus as an immunological smokescreen: A major step towards harnessing tetanus-based therapeutics In: Molecular Immunology, 127, 164 - 174
- Francis, J.,Skakic, I.,Dekiwadia, C.,Shukla, R.,Taki, A.,Walduck, A.,Smooker, P. (2020). Solid lipid nanoparticle carrier platform containing synthetic TLR4 agonist mediates non-viral DNA vaccine delivery In: Vaccines, 8, 1 - 16
- Pourjavaheri, F.,Ostovar, S.,Jones, O.,Smooker, P.,Brkljaca, R.,Sherkat, F.,Blanch, E.,Gupta, A.,Shanks, R. (2019). Extraction of Keratin from Waste Chicken Feathers Using Sodium Sulfide and L-cysteine In: Process Biochemistry, 82, 205 - 214
- Jayaraj, R.,Kumarasamy, C.,Norbury, L.,Piedrafita, D.,Smooker, P. (2019). Protective efficacy of liver fluke DNA vaccines: A systematic review and meta-analysis: Guiding novel vaccine development In: Veterinary Parasitology, 267, 90 - 98
- Aibinu, I.,Smooker, P.,Lopata, A. (2019). Anisakis Nematodes in Fish and Shellfish- from infection to allergies In: International Journal for Parasitology: Parasites and Wildlife, 9, 384 - 393
2 PhD Current Supervisions34 PhD Completions
- Novel, Innovative modified tetanus toxin drugs for weak muscle conditions (administered by Snoretox Pty Ltd). Funded by: MRFF - 2021 Chronic Respiratory Conditions Grant from (2021 to 2023)
- Development of a live vaccine for gut health in poultry. Funded by: ARC Linkage Grant 2016 from (2016 to 2022)
- Nanocapsules made from pure antigenic protein- evaluation of potential as new-generation vaccines. Funded by: The CASS Foundation Science and Medicine Grants 2014 from (2015 to 2016)
- Bioremediation of contaminated radioactive waste. Funded by: Australia Japan Foundation from (2013 to 2014)
- Radiotherapy dose enhancement by scintillating nanoparticles. Funded by: The CASS Foundation Science and Medicine Grant pre-2014 from (2012 to 2013)