Smart stitches to reduce infection, simplify post op monitoring

Smart stitches to reduce infection, simplify post op monitoring

A new antimicrobial suture material that glows in medical imaging could be a promising alternative for mesh implants and internal stitches.

Surgical site infections are one of the most common medical infections, occurring in 2 to 4% of patients post-surgery. For some procedures, such as vaginal mesh implants to treat prolapse, infection rates can be much higher, leading to a ban on that procedure in 2018 in Australia.

Study lead author and Vice Chancellor’s Senior Research Fellow, Dr Shadi Houshyar, said their suture was being developed in partnership with clinicians specifically for this type of procedure.

“Our smart surgical sutures can play an important role in preventing infection and monitoring patient recovery and the proof-of-concept material we’ve developed has several important properties that make it an exciting candidate for this,” said Houshyar, from RMIT University’s School of Engineering.

Lab tests on the surgical filament, published in OpenNano, showed it was easily visible in CT scans when threaded through samples of chicken meat, even after three weeks.

The filament visible in chicken samples, as seen under CT scan. The filament visible in chicken samples, as seen under CT scan.

It also showed strong antimicrobial properties, killing 99% of highly drug-resistant bacteria after six hours at body temperature.

Houshyar said the team was not aware of any commercially available suture products that combined these properties.

How they did it

The multidisciplinary team led by RMIT – included nano-engineering, biomedical and textile experts working in partnership with a practicing surgeon – used the university’s cutting-edge textile manufacturing facility to develop their proof-of-concept material.

The suture’s properties come from the combination of iodine and tiny nanoparticles, called carbon dots, throughout the material. 

Carbon dots are inherently fluorescent, due to their particular wavelength, but they can also be tuned to various levels of luminosity that easily stand out from surrounding tissue in medical imaging. 

Attaching iodine to these carbon dots, meanwhile, provides them with their strong antimicrobial properties and greater X-ray visibility.

Houshyar said carbon nano dots were safe, cheap and easy to produce in the lab from natural ingredients. 

“They can be tailored to create biodegradable stitches or a permanent suture, or even to be adhesive on one side only, where required,” she said. 

“This project opens up a lot of practical solutions for surgeons, which has been our aim from the start and the reason we have involved clinicians in the study.”

Professor Elisa Hill-Yardin, Dr Shadi Houshyar and Professor Justin Yeung inspect a prototype of the iodine-infused filament. Professor Elisa Hill-Yardin, Dr Shadi Houshyar and Professor Justin Yeung inspect a prototype of the iodine-infused filament.

Clinical possibilities

Consultant colorectal surgeon and Professor of Surgery at the University of Melbourne, Justin Yeung, was involved in the study. He said it addressed a real challenge faced by surgeons in trying to identify the precise anatomical location of internal meshes on CT scans.

"This mesh will enable us to help with improved identification of the causes of symptoms, reduce the incidence of mesh infections and will help with precise preoperative planning, if there is a need to surgically remove this mesh,” he said.

“It has the potential to improve surgery outcomes and improve quality of life for a huge proportion of women, if used as vaginal mesh for example, by reducing the need for infected mesh removal.”

“It may also significantly reduce surgery duration and increase surgical accuracy in general through the ability to visualise mesh location accurately on preoperative imaging.” 

Consultant colorectal surgeon at Western Health and Professor of Surgery at the University of Melbourne, Justin Yeung, was involved in the study. Consultant colorectal surgeon at Western Health and Professor of Surgery at the University of Melbourne, Justin Yeung, was involved in the study.

Next steps

Study co-author from RMIT’s School of Health and Biomedical Sciences, Professor Elisa Hill-Yardin, said the next steps were pre-clinical trials. 

“While this research is at an early stage, we believe we are onto something very promising that could help a lot of people and are really keen to speak with industry partners who are interested in working with us to take it further,” she said. 

“We see potential especially in vaginal mesh implants and similar procedures.”

The research team used Australia’s leading university-based textile manufacturing facilities at RMIT’s Centre for Materials Innovation and Future Fashion, as well as the Rapid Discovery and Fabrication team's labs to produce the proof-of-concept material.

Next, they will produce larger suture samples to use in pre-clinical trials, which they have just received seed funding for from RMIT. 

‘Smart suture with iodine contrasting nanoparticles for computed tomography’ is published in OpenNano (DOI: 10.1016/j.onano.2022.100120).

 

Story: Michael Quin

01 February 2023

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