Dr Kylie Quinn is a Vice-Chancellor's Research Fellow at RMIT with extensive research experience in vaccines, immunotherapeutics, and ageing. After a PhD in New Zealand on vaccine strategies for Tuberculosis, Dr Quinn took post-doctoral positions in Dr Robert Seder's lab (2008-13; Vaccine Research Center, NIH), where she defined the mechanism of action for a number of novel vaccines and provided key pre-clinical data for Ebola vaccine selection by the World Health Organisation in 2014, and in Prof Nicole La Gruta's lab (2013-18; University of Melbourne, Monash University), where she developed a project on how ageing limits the function of immune cells known as CD8 or "killer" T cells.
Dr Quinn's research group at RMIT focuses on developing ways to improve immune responses in the elderly during infection, vaccination and cell-based therapies. In particular, she aims to refine chimeric antigen receptor T cell therapy (CTT), where a sample of a patient's 'killer' immune cells are activated in the lab, modified with a cancer-seeking receptor and transferred back into the patient, where they kill cancerous cells. It can achieve remarkable remission rates, but it is less successful in older patients, as their immune cells are difficult activate. Her work aims to identify what limits this activation and to remove that barrier, thereby tailoring CTT for the elderly. Dr Quinn also has a longstanding interest in issues around equity and diversity and is the Women's Initiative Co-ordinator for the Australia and New Zealand Society of Immunology (ASI).
Summary of activities
Vice-Chancellor's Research Fellow and Group Leader of "Ageing and Immunotherapies"
Supervision of undergraduate research placement students, post-graduate Honours, Masters and PhD students.
Australia and New Zealand Society of Immunology (ASI) Women's Initiative Co-ordinator
- B.Sc (Hons; 1st class, Genetics), conferred by University of Otago, New Zealand, 2004
- PhD (Cell Biology), conferred by Victoria University of Wellington hosted at the Malaghan Institute of Medical Research, 2008
- Ly Hun, M.,Wong, K.,Gunawan, J.,Alsharif, A.,Quinn, K.,Chidgey, A. (2020). Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage In: Frontiers in immunology, 11, 1 - 20
- Loh, L.,Gherardin, N.,Sant, S.,Flanagan, K.,Quinn, K. M., et al, . (2020). Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRa� Clonotypes with Potent Antimicrobial Responses In: Journal of Immunology, 204, 1119 - 1133
- Mangas, K.,Buultjens, A.,Porter, J.,Quinn, K., et al., . (2020). Vaccine-specific immune responses against mycobacterium ulcerans infection in a low-dose murine challenge model In: Infection and Immunity, 88, 1 - 20
- Smith, C.,Venturi, V.,Quigley, M.,Quinn, K. et al, . (2020). Stochastic expansions maintain the clonal stability of CD8+ T cell populations undergoing memory inflation driven by murine cytomegalovirus In: Journal of Immunology, 204, 112 - 121
- Quinn, K.,Kartikasari, A.,Cooke, R.,Koldej, R.,Ritchie, D.,Plebanski, M. (2020). Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy. In: Journal of leukocyte biology, 108, 953 - 965
- Quinn, K.,Hussain, T.,Kraus, F.,Formosa, L. E., et al, . (2020). Metabolic characteristics of CD8+ In: Nature Communications, 11, 1 - 12
- Cooke, R.,Quinn, K.,Quach, H.,Harrison, S.,Prince, H.,Koldej, R.,Ritchie, D. (2020). Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells In: Frontiers in Immunology, 11, 1 - 10
- Sng, X.,Li, J.,Zareie, P.,Assmus, L.,Lee, J.,Jones, C.,Turner, S.,Daley, S.,Quinn, K.,La Gruta, N. (2020). The impact of MHC class I dose on development and maintenance of the polyclonal naive CD8+ T cell repertoire In: Journal of Immunology, 204, 3108 - 3116
- Quinn, K.,Palchaudhuri, R.,Palmer, C.,La Gruta, N. (2019). The clock is ticking: the impact of ageing on T cell metabolism In: Clinical and Translational Immunology, 8, 1 - 19
- von Scheidt, B.,Wang, M.,Oliver, A.,Quinn, K., et al, . (2019). Enterotoxins can support CAR T cells against solid tumors In: Proceedings of the National Academy of Sciences of the United States of America, 116, 25229 - 25235
- Identifying novel targets for treating the diseases of the brain: microglial metabolism as a treatment option. Funded by: CASS Foundation - grant from (2021 to 2022)
- Tailoring the Next Generation of Cancer Treatment for an Older Generation of Patients. Funded by: Rebecca L. Cooper Medical Research Foundation - Al and Val Rosenstrauss Fellowship 2018 from (2019 to 2022)
2 PhD Current Supervisions