Jiali (Maggie) Zhai

Associate Professor Jiali (Maggie) Zhai

Associate Professor

Details

Open to

  • Masters Research or PhD student supervision

About

Dr Jiali (Maggie) Zhai is an Associate Professor of chemistry in School of Science, and is one of the HDR managers within the school. Prior to joining RMIT, she was awarded a CSIRO Office of the Chief Executive Postdoctoral Fellowship. She obtained her PhD in Biochemistry from Monash University.

 

A/Prof Zhai leads a multidisciplinary and diverse research group working at the interface of materials engineering, biomedical engineering, nanotechnology, chemical engineering, biochemistry, colloid and surface science, and advanced synchrotron science. Her research spans polymers, soft matter, lipids, proteins, carbon-based materials, porous materials, hydrogels, microgels, 3D-printed materials and functional biomaterials, with applications in drug delivery, controlled release, tissue regeneration, health and food technologies. A/Prof Zhai has extensive expertise in synchrotron- and neutron-based techniques, including small-angle X-ray scattering, spectroscopy, circular dichroism, X-ray fluorescence microscopy, small-angle neutron scattering and neutron reflectometry, and their application across diverse materials engineering systems. Her research using high-throughput combinatorial synthesis and synchrotron SAXS has made significant contributions to understanding lipid and polymer self-assembly in complex systems, including ternary and quaternary systems of responsive ionisable lipids, block copolymers, proteins, hydrogels, phospholipids, fatty acids, ionic additives, emulsions and food materials.


A/Prof Zhai has attracted research funding of over $3m from ARC, NHMRC, ANSTO, CSIRO, mRNA Victoria, CASS Foundation, Dust Diseases Board, and a range of university and organisational schemes, as both lead Chief Investigator and co-Chief Investigator. Her international research standing is demonstrated by publications in leading journals including JACS, Angewandte Chemie, ACS Nano, Advanced Science, Advanced Functional Materials and Accounts of Chemical Research, as well as numerous invited plenary and keynote presentations at international conferences. She has published over 80 journal articles, with more than 4,000 citations and an h-index of 38. To date, she has supervised 8 PhD students to completion. She was awarded a Victoria Fellowship (2020), an Australasian Colloid and Interface Society Lectureship (2022), and an ANSTO Research Award (2023). She is also a recipient of the Australian Academy of Science European Mobility Grant 2025. 

 

A/Prof Zhai currently serves as the Chair of the Australian Synchrotron User Advisory Committee (UAC) and the Treasurer of the Australian Chapter of the Controlled Release Society. 

Research fields

  • 401605 Functional materials
  • 340603 Colloid and surface chemistry
  • 310607 Nanobiotechnology
  • 400302 Biomaterials

UN sustainable development goals

  • 3 Good Health and Well Being
  • 9 Industry, Innovation and Infrastructure

Supervisor projects

  • Unravelling the role of the liver-lung axis during secondary bacterial pneumonia
  • 25 Nov 2025
  • Understanding the role of biomolecular corona on nanoparticle-cell interactions for biomedical applications
  • 1 Oct 2025
  • Novel Hybrid Nanomaterial
  • 15 Jul 2025
  • Deciphering lipid-RNA nanocarrier structure upon RNA complexation
  • 25 Feb 2025
  • Developing bile salt and ionic liquid-lipid nanocomplex for oral delivery of nucleic acid
  • 24 Jan 2025
  • Investigating physicochemical and toxic properties of lipid nanoparticles as prospective drug carriers
  • 23 Jan 2025
  • Carbon Dot-based Hydrogel Multifunctional Platforms for Biosensors
  • 25 Nov 2024
  • Enhancing functional properties and health benefits of novel modified starches
  • 9 Oct 2024
  • External Stimulation of Stem Cells for Tissue Engineering
  • 28 Feb 2024
  • Developing organ-targeted lipid nanoparticles for mRNA delivery
  • 22 Feb 2024
  • Developing organ-targeted lipid nanoparticles for mRNA delivery
  • 20 Nov 2023
  • Scalable Floating Photocatalytic Device for Hydrogen Production from Open Water
  • 2 May 2023
  • Reversible Carbon Dioxide Conversion for Clean Energy Production
  • 14 Feb 2023
  • Develop advanced injectable bioactive hydrogels for improving tissue regeneration
  • 9 Dec 2022
  • Novel Responsive Lipid Nanoparticles for Multidrug-Resistant Organism Therapeutics
  • 24 Aug 2022
  • Developing Novel ALOX5 mRNA Nanoparticles To Treat Incurable Non-Small Cell Lung Cancer
  • 24 Feb 2022
  • Self-assembled Lipid Nanoparticles for Targeted Cancer Therapeutics
  • 7 Apr 2021
  • Biocompatible Ionic Liquids as Designer Solvents for Non-lamellar Lyotropic Liquid Crystalline Nanoparticles
  • 9 Jun 2020
  • Development and Application of Novel pH-responsive Lipid Nanoparticles for Anticancer and Antifungal Drug Delivery
  • 2 Dec 2019
  • Molecular Insights into Amyloid Toxicity Using Model Lipid Membranes
  • 2 Mar 2015

Teaching interests

Teaching

Physical Sciences in Action (ONPS2701)

 

Research interests

Functional Materials, Nanobiotechnology, mRNA Therapeutics, Colloids and Interface Science, Lipid Nanoparticles, Macromolecular and Materials Chemistry, Food Sciences, Medicinal and Biomolecular Chemistry, Other Chemical Sciences


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