NHMRC project "Engineered drugs that specifically inhibit clotting "

NHMRC project "Engineered drugs that specifically inhibit clotting "

This project utilises fluid mechanics, microfluids and machine learn to develop rapid testing methods for novel drugs invitro.

Overview

Myocardial infarction (heart attack) and stroke remain leading causes of global death and disability. This PhD project is part of a large NHMRC-funded initiative aiming to develop engineered drugs that specifically inhibit clotting in specific sites, and eliminating the risk of major bleeding complications associated with conventional anticoagulant therapies. By integrating computational modelling, biomimetic microfluidic, and advanced data analysis, this research aims to deliver innovative solutions to global health challenges

Project objectives

1. Design and Testing of Biomimetic Microfluidic Systems

  • Utilise computational fluid dynamics (CFD) to design microfluidic layouts that replicate diverse cardiac arterial geometries.
  • Fabricate the selected microfluidic designs in RMIT's cleanroom facilities.
  • Test the functional performance of these designs using micro particle image velocimetry (uPIV).

2. Integration of Machine Learning for Experimental Optimisation

  • Employ machine learning and Al to optimise the experimental parameter space, minimising the need for extensive experimental variations.

3. Validation with Real Blood Samples

  • Conduct testing of microfluidic chips with real blood samples in collaboration with Monash University.
  • Generalise findings across various thrombotic conditions to enhance the applicability of results.
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$41,000 per year tax free

Applications are now open.

30/11/2025

1 (one)

This project is suited to engineering students with experience or a strong interest in at least one of the following areas:

  • Fluid dynamics
  • Microfabrication
  • Machine learning and Al
  • Physiology.

For further details, please contact:

To apply, please send your CV and academic transcript to one of the above.

Research Environment: The PhD student will primarily be based at RMIT's city campus, leveraging advanced facilities such as the cleanroom and fluid dynamics laboratories. Periodic travel to Monash University's Clayton campus will be required for blood-based experimentation and further analysis. 

Applicant should have interest in fluid mechanics, microfabrication, Al and a first class honours degree or equivalent.

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Acknowledgement of Country

RMIT University acknowledges the people of the Woi wurrung and Boon wurrung language groups of the eastern Kulin Nation on whose unceded lands we conduct the business of the University. RMIT University respectfully acknowledges their Ancestors and Elders, past and present. RMIT also acknowledges the Traditional Custodians and their Ancestors of the lands and waters across Australia where we conduct our business - Artwork 'Sentient' by Hollie Johnson, Gunaikurnai and Monero Ngarigo.

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