PhD abstract: Study of Quorum Sensing (QS)-Driven Inhibitors for Mitigating Microbially Influenced Corrosion of Carbon Steel

Asma Lamin

Microbiologically influenced corrosion (MIC) is a process by which microorganisms initiate, facilitate, or accelerate the electrochemical corrosion reactions of metallic components. Several studies report that MIC accounts for 20-40% of the total cost of corrosion. For example, MIC in oil & gas pipelines can result in significant production loss & serious environmental damage. Biofilm formation caused by surface microorganisms upon metal components is known to play a vital role in MIC. The QS biofeedback system plays a significant role in controlling the expression of some bacterial enzymes, e.g. catalase regulates biofilm formation and thus the overall MIC rate for metal. As such, avoiding biofilm formation via inhibiting QS is a potentially sound strategy for mitigating MIC of metal. This PhD aims to elucidate the mechanistic role of QS both in biofilm formation & corrosion of carbon steel, a prevalent engineering material for construction of pipelines, with Pseudomonas aeruginosa used as a model organism.

LuxI/LuxR QS in Gram-negative bacteria. LuxI is an autoinducer synthase and LuxR is an AHL receptor protein. At high cell density, AHL autoinducer binds to LuxR and activates the transcription of its target genes. Figure 1: LuxI/LuxR QS in Gram-negative bacteria. LuxI is an autoinducer synthase and LuxR is an AHL receptor protein. At high cell density, AHL autoinducer binds to LuxR and activates transcription of its target genes

Project Publications

A Lamin, AH Haksonen, IS Cole & X-B Chen (2022). ‘Quorum sensing inhibitors applications: A new prospect for mitigation of microbiologically influenced corrosion’, Bioelectrochemistry, 145, 108050, DOI: 10.1016/j.bioelechem.2022.108050.

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Corrosion and Inhibition

Corrosion inhibitors, corrosion of steel pipes in a soil environment, photocatalysts for CO2 hydrogenation, nano-sensing, optical sensing.

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Acknowledgement of Country

RMIT University acknowledges the people of the Woi wurrung and Boon wurrung language groups of the eastern Kulin Nation on whose unceded lands we conduct the business of the University. RMIT University respectfully acknowledges their Ancestors and Elders, past and present. RMIT also acknowledges the Traditional Custodians and their Ancestors of the lands and waters across Australia where we conduct our business - Artwork 'Luwaytini' by Mark Cleaver, Palawa.

aboriginal flag
torres strait flag

Acknowledgement of Country

RMIT University acknowledges the people of the Woi wurrung and Boon wurrung language groups of the eastern Kulin Nation on whose unceded lands we conduct the business of the University. RMIT University respectfully acknowledges their Ancestors and Elders, past and present. RMIT also acknowledges the Traditional Custodians and their Ancestors of the lands and waters across Australia where we conduct our business.