This project aims to develop a functional strontium (Sr)-release surface upon magnesium-based orthopaedic implants to suppress the rapid degradation rate of Mg, facilitate new bone formation and ultimately shorten healing process. The project will establish theunderstanding of the formation mechanisms of Sr-releasing coatings, and determine the critical release rate of Sr to activate bone cell responses. The project is significant for the development of practical, bone-favourable and degradation-inhibiting surfaces for magnesium implants, which are in demand and can bring significant patient benefits. The project will forge new and important collaborations and provide an output for biomedical technology locally and internationally.
Figure 1. Bioactivity evaluation of Mg implants (Sham: no implant; SrPO₄@Mg: pure Mg with strontium phosphate coating, Pure Mg: bare Mg implant) in mice model for 7 weeks - (top row) Bone tissue response to the implanted rods - µCT analysis. (bottom row) quantitative results of new bone formation at the implant sites of mice femur after 7 weeks’ implantation.
The project is supported by ARC Linkage project LP150100343 'Functional Strontium Phosphate Coated Magnesium Alloys For Orthopaedic Use'. Visit the project's grant page on the ARC website for more information.
Corrosion and Inhibition
Corrosion inhibitors, corrosion of steel pipes in a soil environment, photocatalysts for CO2 hydrogenation, nano-sensing, optical sensing.
