Research interests
The focus of the research of the Oxidant and Inflammation Biology (OXIB) Group is to identify novel therapeutics for viral diseases and cancer. The research program has 4 major projects and for each project there is a strong integration with collaborators at RMIT (Profs Ross Vlahos and Steven Bozinovski), and both nationally (Prof Doug Brooks; UniSA) and internationally (Prof John O'Leary; Trinity College Dublin).
The first project focusses on the development of novel therapeutics for viruses including influenza, rhinovirus, Dengue virus and COVID-19. With ViraLokTherapeutics we are developing antiviral and anti-inflammatory drugs that thus far have shown good efficacy in pre-clinical models.
The second project of OXIB's ongoing research program is to develop therapeutics for viral diseases in livestock industries. This originated from our highly visible Nature Communications paper that provides evidence of a drug targetable process that underpins viral disease in animals. Pig and poultry industries suffer significantly from viral diseases that are a major animal welfare issue; a global economic burden and a critical source of viral species that ultimately transmit to man and cause global pandemics.
The third project aims to unravel fundamental viral disease mechanisms in athigh risk populations such as pregnant women and cardiovascular patients. Viruses cause more significant disease in these cohorts and our research has thus far identified novel mechanisms of this exacerbated disease and novel therapeutic strategies. Virus infections in pregnancy also lead to significant complications for the offspring, in particular, maternal infection has been associated with neurodevelopmental disorder including schizophrenia. This work is an ongoing collaboration with Monash University (Prof Arthur Christopoulos) and The University of Melbourne (Prof Christos Pantelis).
The fourth project is part of an international research program for cancer and cancer metastasis in collaboration with researchers from UniSA (Prof Doug Brooks) and Trinity College Dublin (Prof John O’Leary). This research program is funded by NHMRC and Industry, in particular, Envision Sciences Pty Ltd. OXIB's role in this major global collaborative network is to provide critical pre-clinical models to test the efficacy of our novel therapeutics against prostate cancer; unravel diagnostic markers and biomarkers of cancer pathogenesis. This line of research and engagement is achieved by an amalgamation, of OXIB’s activities with those of Profs Doug Brooks and John O’Leary and the industry partner Envision Sciences Pty Ltd.
Research keywords:
Respiratory Disease, Cardiovascular Disease, Drug Discovery, Pharmacology, Influenza, Common Cold, COVID-19, Virus, Inflammation