Rob was appointed Professor of Biotechnology at RMIT University in February 2015. He started his career as an EMBO Post-doctoral Fellow in The University of Edinburgh, UK, followed by a Post-doctoral Fellowship at the Imperial Cancer Research Laboratories, London UK. He then returned to Australia to work within the R&D Department of a multinational animal health company where he worked on anti-parasite vaccines and biological defleecing. He established and managed a fermentation production facility for recombinant protein production. He then moved to the Commonwealth Scientific and Industrial Research Organisation (CSIRO) where his group worked on a wide range of externally funded research projects including: studies of the molecular basis of bacterial pathogenesis; develop of vaccines; host responses to pathogens; use of RNA interference for gene silencing; microRNA biology; antimicrobial protein expression systems and in vivo use; and the role of gut microbiota in health and productivity.
- Moore, R.J., Rood, J.I, and Keyburn, A.L. Clostridial Toxin NetB. US Patent no. 8,263,088 B2. Application date: 8 June 2007, Patent issue date: 11 September 2012.
- Moore, R.J., Rood, J.I, and Sheedy, S.A. Bacterial delivery of biologically active polypeptides, US Patent no. 8,066,987 B2. Application date: 29 August 2006, Patent issue date: 29 November 2011. Australian Acceptance date: 29 March 2012. PCT publication date: 8 March 2007, WO 2007/025333 A1.
- Sinclair, A., Smith, C., Doran, T.J., Moore, R.J., and Lowenthal, J.W. Sex-determination and methods of specifying same. Priority date: 8 February 2010. International patent Application PCT/AU2010/000133. US Application 2012/0084873 A1.
- Doran T., Moore R., Tyack S., Lowenthal J.W. and McKay J. Treatment and prevention of influenza. Priority date: 16 May 2007. International Patent Application PCT/AU2008/000692. 16 May 2008. WO 2008/138072 A1.
- Doran T., Moore R., and Lowenthal J.W. Modulating production traits in avians. Priority date: 13 June 2007. International Publication No. WO 2008/151364 A1. US International Patent Application Filed June 2008.
- Waterhouse, P.M., Lockett, L.J., Wang, M., Doran, T.J., Moore, R.J., and Both, G.W. Modified gene-silencing nucleic acid molecules and uses thereof. Priority date: 10 September 2004. International Publication No. WO 2005/026356 A1. US Application 2008/0044906 A1.
- Moore, R.J., and Doran, T. Methods of identifying antigen gene sequences. Australian patent No. 764256, US patent No. 6,759,516 B2. Date of patent: 6 July 2004.
- Shepherd, S., and Moore, R. Stabilised polypeptide growth factor formulation at low pH. International Publication No. WO 95/02411.
- Moore, R.J. Recombinant Growth factors. International Publication No. WO 91/05863.
Recent conference presentations
- Invited Speaker. The use of metagenomics to investigate the role of microbiota in animal health and productivity. Robert J. Moore. Agriculture and Food Biotechnology Symposium, AusBiotech 2014 Conference, Gold Coast, Australia, October 2014.
- Invited Speaker. The ups and downs in gut microbiota associated with poultry performance. Robert J. Moore, Dragana Stanley, and Robert J. Hughes. Poultry Science Association, Corpus Christi, Texas, USA, July 2014.
- Maternal immunization with NetB-based vaccines protect broiler chickens from necrotic enteritis. Anthony L. Keyburn, Ricardo Dias Portela, Mark E. Ford, Trudi Bannam, Xuxia Yan, Julian I. Rood, and Robert J. Moore. Poultry Science Association, Corpus Christi, Texas, USA, July 2014.
- Invited Speaker. Spotty liver disease – what is the cause? Robert Moore, Dana Stanley, Theo Allnutt, Honglei Chen and Peter Scott. Australian Veterinary Poultry Association Meeting, Gold Coast, Australia, May 2014.
- Invited Speaker. Phylogenetic profiling of gastrointestinal microbiota. Robert J. Moore. Metagenomics@Melbourne Symposium, Bio21, Melbourne, Australia, November 2013.
- Invited Speaker. Impact of gut microbiota on productivity of chickens. Robert J. Moore. Australian Veterinary Poultry Association Meeting, Adelaide, Australia, October 2013.
- Invited Speaker. Towards registration of a NetB vaccine. Robert J. Moore. Poultry CRC Ideas Exchange, Gold Coast, Australia, September 2013.
- NetB-based vaccines protect broiler chickens from necrotic enteritis. Anthony L. Keyburn, Ricardo Dias Portela, Kathy Sproat, Mark E. Ford, Trudi L. Bannam, Xuxia Yan, Julian I. Rood, and Robert J. Moore. The Prato Conference of the Pathogenesis of Bacterial Diseases of Animals, VetPath 2012, Italy, October 2012.
- Live bacterial vectors for the delivery of therapeutic proteins to the gastrointestinal tract of chickens.Robert J. Moore, David P. Stevenson, Scott A. Sheedy, Volker Haring, Gwen E. Allison, and Julian I. Rood. International Symposium: Alternative to Antibiotics, Paris, France, September 2012.
- Intestinal microbiota associated with high feed conversion efficiency in chickens. Robert J. Moore, Stuart E. Denman, Mark S. Geier, and Dragana Stanley. International Symposium: Alternative to Antibiotics, Paris, France, September 2012.
- Vaccination with NetB toxin protects broiler chickens from necrotic enteritis. Anthony L. Keyburn, Ricardo D. Portela, Mark E. Ford, Trudi Bannam, Xuxia Yan, Julian I. Rood, Robert J. Moore. 6th International Veterinary Vaccines and Diagnostics Conference, Cairns, Australia, July 2012.
- The gut microbiota’s role in chicken productivity. Dana Stanley, Mark S. Geier, Robert J. Hughes, Robert J. Moore. Australian Poultry Science Symposium, Sydney, Australia, February 2012.
Professor Moore’s newly established laboratory at RMIT University has three main research themes:
- Development of vaccines against animal pathogens.
- Understanding the role of microbiota in the promotion of health and animal productivity.
- The development of bacteria from the gut microbiota for use as probiotics and live recombinant protein delivery vectors.
Research within these themes use the latest developments in molecular biology and involve collaborations with groups at RMIT and other universities and research institutes.
Over the last 10 years much of Professor Moore’s research has been supported by the Poultry Cooperative Research Centre and hence has focused on disease and productivity research for the chicken industries. Of particular note is the contribution that his group, in collaboration with others, has made to understanding the pathogenesis of the bacterial disease necrotic enteritis; a disease which has been estimated to cost the global poultry industry over $2 billion dollars per year. They identified the major virulence factor NetB within the pathogen Clostridium perfringens and are currently working to develop a vaccine for the broiler industry.
- BSc(Hons) Monash University, 1978
- PhD Monash University, 1982
Professor Moore worked for 8 years in an animal health company (Coopers; Pitman-Moore) and following that has extensive experience as a researcher working on industry funded projects. He understands the commercial imperatives of industry.
Professional memberships and activities
- Honorary Fellow, CSIRO Biosecurity Flagship, 2014 - Present
- Adjunct Associate Professor, Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, 2002 – Present
- Associate, ARC Centre of Excellence in Structural and Functional Microbial Genomics, 2006 – 2013
- Board Member (Founding), Victorian Infection and Immunity Network, 2006 – 2014
- Project Leader in the Poultry Co-operative Research Centre, 2003 – Present
- Editorial board member of journal “Biotechnology and Applied Biochemistry”, 1996-2006
- Member: Australian Society for Microbiology
- Member: American Society for Microbiology
- Member: Poultry Science Association (USA)
- Member of the Australian Government's Gene Technology Technical Advisory Committee (GTTAC), 2008-2014
- Regular reviewer for a wide range of granting agencies and journals.
- Cooper, C.,Tizard, M.,Stanborough, T.,Moore, S.,Moore, R., et al., . (2019). Overexpressing ovotransferrin and avian �-defensin-3 improves antimicrobial capacity of chickens and poultry products In: Transgenic Research, 28, 51 - 76
- Moore, R. (2019). The importance of gut microbiota in chickens with particular emphasis on the field situation In: Proceedings of the Australian Poultry Science Symposium, Volume 30, 2019, Sydney, Australia, 17th-20th February 2019
- Van, T.,Lacey, J.,Vezina, B.,Phung, V.,Anwar, A.,Scott, P.,Moore, R. (2019). Survival Mechanisms of Campylobacter hepaticus Identified by Genomic Analysis and Comparative Transcriptomic Analysis of in vivo and in vitro Derived Bacteria In: Frontiers in Microbiology, 10, 1 - 19
- Willson, N.,Van, T.,Bhattarai, S.,Courtice, J.,McIntyre, J.,Prasai, T.,Moore, R.,Walsh, K.,Stanley, D. (2019). Feed supplementation with biochar may reduce poultry pathogens, including Campylobacter hepaticus, the causative agent of Spotty Liver Disease In: PLoS ONE, 14, 1 - 16
- Lacey, J.,Johanesen, P.,Lyras, D.,Moore, R. (2019). In silico identification of novel toxin homologs and associated mobile genetic elements in clostridium perfringens In: Pathogens, 8, 1 - 14
- Moore, R.,Scott, P.,Van, T. (2019). Spotlight on avian pathology: Campylobacter hepaticus, the cause of Spotty Liver Disease in layers In: Avian Pathology, 48, 285 - 287
- Reichelt, A.,Loughman, A.,Bernard, A.,Raipuria, M.,Abbott, K.,Dachtler, J.,Van, T.,Moore, R. (2019). (In Press) An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats In: Nutritional Neuroscience: An International Journal on Nutrition, Diet and Nervous System, , 1 - 15
- Moore, R.,Lacey, J. (2019). Genomics of the Pathogenic Clostridia In: Microbiology spectrum, 7, 1 - 17
- Ma, L.,Cong, F.,Zhu, Y.,Wu, M.,Xu, F.,Huang, R.,Moore, R.,Guo, P. (2018). Development of a reverse transcription recombinase polymerase amplification assay for rapid detection of Theiler's murine encephalomyelitis virus In: Molecular and Cellular Probes, 41, 27 - 31
- Lacey, J.,Stanley, D.,Keyburn, A.,Ford, M.,Chen, H.,Johanesen, P.,Lyras, D.,Moore, R. (2018). Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota In: Veterinary Microbiology, 227, 119 - 126
- Phytobiotic potential for control of Spotty Liver Disease. Funded by: National Feed Solutions Pty Ltd - Competitive from (2019 to 2020)
- Identification of virulence factors that cause liver damage in SLD. Funded by: Australian Eggs Limited - Grant from (2019 to 2020)
- Development of immunological assays to assist the control of Spotty Liver Disease in chickens. Funded by: PoultryHub Australia from (2019 to 2020)
- Next generation probiotics to enhance the gut health of chickens. Funded by: 095-AgriFutures Australia (Rural Industries R&D Corporation Open Call Research and Development Projects) 2017 from (2018 to 2021)
- Study of gut microbiota of laying hens from different production systems (Administered by University of Adelaide). Funded by: Australian Eggs Limited - Grant from (2018 to 2020)
7 PhD Current Supervisions and 1 Masters by Research Current Supervisions